Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
About this study
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \~5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
- Condition
- Diabetes Mellitus Type 2
- Tested
- Inspiratory Muscle Strength Training (IMST), Sham Training
- Sponsor
- Seattle Children's Hospital
Who can join
- Age
- 14 to 40 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 3
- Minimum age: 14 years
- Maximum age: 40 years
- Study condition: Diabetes Mellitus Type 2
Where
2 sites, 2 recruiting
Seattle Children's Hospital
Seattle, Washington, United States
University of Washington Medicine Diabetes Institute
Seattle, Washington, United States
Contact
-
Kalie Tommerdahl, MD
(206) 616-9015 ktomme@uw.edu
Potential match only. Final eligibility is determined by the study team.