Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
About this study
Sickle cell disease is a chronic disease characterized by multiple vaso-occlusive complications. The basic treatment for patients with a vaso-occlusive crisis (VOC) is based on adequate hydration, oxygen therapy and pain control. Loco Regional Anesthesia (LRA) is one of the major treatments in resuscitation anesthesia for both anesthesia and analgesia. LRA allows effective and almost immediate pain control by blocking nerve afferents in a given area. LRA could decrease the inflammatory response during crises and accelerate resolution of the crisis.
- Condition
- Sickle Cell, Sickle Cell Disease, Vaso-Occlusive Crises
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 4
- Minimum age: 18 years
- Study condition: Sickle Cell, Sickle Cell Disease, Vaso-Occlusive Crises
- patients adult \>18 years
- patients with vaso-occlusive crisis
Exclusion 4
- Pregnant or breastfeeding women
- Blood transfusion within the last 3 months
- Lack of affiliation with the French social security system
- Protected individuals
Where
1 site, 1 recruiting
Chu de La Guadeloupe
Pointe-à-Pitre, Guadeloupe
Contact
-
Valérie Hamony Soter
+590590934677 valerie.soter@chu-guadeloupe.fr
-
Mélanie Petapermal
+590590934667 melanie.petapermal@chu-guadeloupe.fr
Potential match only. Final eligibility is determined by the study team.