Olfactory Biopsies
About this study
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.
- Condition
- Alzheimer Disease, Smell Loss, Smell Dysfunction
- Tested
- olfactory testing, Odor stimulation, Olfactory biopsy
- Sponsor
- Duke University
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 9
- Minimum age: 18 years
- Study condition: Alzheimer Disease, Smell Loss, Smell Dysfunction
- Group 1: Alzheimer's study
- Between the ages of 18 and 80
- Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
- Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
- Age 18 years or older
- Patients being seen for rhinology or olfactory disorders
- Patients having unrelated endoscopic nasal surgery
Exclusion 10
- Advanced Alzheimer's/dementia
- Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
- Active Rhinosinusitis symptoms
- Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
- Parkinson's disease
- Unable or willing to complete the nasal endoscopy procedure.
- Unable to read or speak English
- Unable to provide legally effective consent
- Group 2: Act-seq study or Non-AD controls
- Unable or willing to complete the nasal endoscopy procedure
Where
1 site, 1 recruiting
Duke University Health Center
Durham, North Carolina, United States
Contact
-
Maria J Manson, MBA
(919) 684-0525 maria.manson@duke.edu
-
Bradley J Goldstein, MD, PhD
(919) 684 3834 bradley.goldstein@duke.edu
Potential match only. Final eligibility is determined by the study team.