The Link Between Physical Activity and Brain Health in Healthy Adults
About this study
The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is: Do former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.
- Condition
- Alzheimer Disease, Inactivity, Preventive Therapy
- Sponsor
- Technical University of Madrid
Who can join
- Age
- 40 to 75 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 7
- Minimum age: 40 years
- Maximum age: 75 years
- Study condition: Alzheimer Disease, Inactivity, Preventive Therapy
- Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
- Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
- In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
- Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition
Exclusion 11
- Medical conditions that have a high risk of associated cognitive symptoms.
- Severe head injury with loss of consciousness within the previous 5 years.
- Alcoholism (\>3 alcoholic drinks per day).
- Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
- Hearing or visual impairment that would preclude testing
- History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
- Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
- Presence of severe systemic disease (e.g., cancer under treatment).
- Consumption of anabolic substances.
- Problems understanding spoken or written Spanish.
- Those with pacemakers or metallic implants that may interfere with the MRI.
Where
1 site, 1 recruiting
Faculty of Physical Activity and Sports Sciences (INEF)
Madrid, Madrid, Spain
Contact
-
Songxin Tang
+34 663002621 songxin.tang@alumnos.upm.es
Potential match only. Final eligibility is determined by the study team.