Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
About this study
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
- Condition
- EEG Brain Oscillations, Alzheimer's Disease (AD) and Related Disorders, Cognitive Dysfunction
- Tested
- Gamma auditory stimulation device (active setting), Gamma auditory stimulation device (sham setting)
- Sponsor
- Chang Gung Memorial Hospital
Who can join
- Age
- 60 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 6
- Minimum age: 60 years
- Study condition: EEG Brain Oscillations, Alzheimer's Disease (AD) and Related Disorders, Cognitive Dysfunction
- Age over 60 years old.
- MMSE≤ 24
- CDR scores of 0.5 and 1
- Voluntary to sign the Informed Consent Form.
Exclusion 4
- Diagnosis of other psychiatric or neurological disorders
- Drug or alcohol addictions.
- Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests.
- History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.
Where
1 site, 1 recruiting
Chang Gung University
Taoyuan, Guishan, Taiwan
Contact
-
Chia-Hsiung Cheng, Ph.D.
+886-3-211800 ch.cheng@mail.cgu.edu.tw
Potential match only. Final eligibility is determined by the study team.