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Recruiting Phase 1

Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease

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About this study

To investigate the safety of deep brain stimulation (DBS) and cervical deep lymphoid-venous anastomosis (LVA) in the treatment of severe Alzheimer's disease (AD); to investigate the effectiveness of DBS and LVA in the treatment of severe AD, i.e., effects of deep brain stimulation on cognitive function, emotion and life quality in patients with severe AD.

Condition
Alzheimer Disease
Tested
Deep Brain Stimulation, DBS, Deep cervical lymphatic-venous anastomosis, LVA, Recognized pharmacological treatments for...
Sponsor
Chinese PLA General Hospital

Who can join

Age
40 to 80 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 8

  • Minimum age: 40 years
  • Maximum age: 80 years
  • Study condition: Alzheimer Disease
  • Meeting the diagnostic criteria for dementia formulated by the National Institute on Aging-Alzheimer's Association (NIA-AA).
  • Clinical Dementia Rating (CDR) score of 3 points.
  • Ability to ambulate independently or with the aid of a walker/cane.
  • Adequate visual and auditory capacity to cooperate with examinations and treatment.
  • Voluntary participation with written informed consent provided by both the subject and their legal guardian.

Exclusion 12

  • Pre-existing abnormal brain structure (e.g., tumor, cerebral infarction, hydrocephalus, or intracranial hemorrhage).
  • Comorbidity with other neurological disorders such as multiple sclerosis, epilepsy, or Parkinson's disease.
  • Psychiatric disorders: e.g., anxiety, depression, other affective disorders, or drug-induced psychosis.
  • Severe internal diseases, currently using respiratory/cardiovascular/anticonvulsant/psychotropic drugs, or clinically significant gastrointestinal, renal, hepatic, respiratory, infectious, endocrine, or cardiovascular diseases, cancer, alcoholism, or substance addiction.
  • Severe auditory or visual impairment.
  • Clinical comorbidities with life expectancy \<2 years.
  • History of cranial surgery.
  • Contraindications to MRI or transcranial alternating current stimulation (tACS) (e.g., cardiac pacemaker, post-deep brain stimulation surgery).
  • Eczema or sensitive skin.
  • Familial Alzheimer's disease.
  • Other types of dementia: e.g., vascular dementia, Lewy body dementia, frontotemporal dementia, or infectious dementia;
  • Any other condition deemed by the investigator as unsuitable for the study

Where

1 site, 1 recruiting

Chinese PLA General Hospital

Beijing, China

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.