Phosphorylated Tau Levels in Donated Blood
About this study
Alzheimer's disease (AD) is characterized by the accumulation of tau pathology, and blood-based biomarkers such as phosphorylated tau-217 (pTau217) have been identified as sensitive and specific predictors of AD risk. Recent studies suggest that individuals with elevated pTau217 levels may be at increased risk for developing AD and cognitive dysfunction. This observational study will examine donated human plasma samples to determine whether some units of donated blood contain abnormally elevated pTau217 concentrations. The overarching goal is to evaluate whether transfusion of blood with higher pTau217 may pose risks to recipients and whether such units should be avoided in clinical use.
- Condition
- Alzheimer&Amp;#39;s Disease
- Sponsor
- The University of Texas Health Science Center, Houston
Who can join
- Age
- Not specified
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 2
- Study condition: Alzheimer&Amp;#39;s Disease
- The plasma sample from donators.
Where
1 site, 1 recruiting
University of Texas Health Science Center at Houston
Houston, Texas, United States
Contact
-
Zhongcong Xie, M.D., Ph.D.
17135006207 Zhongcong.Xie@uth.tmc.edu
Potential match only. Final eligibility is determined by the study team.