Non-Invasive Diagnosis and Monitoring of Cardiac Masses by Liquid Biopsy
About this study
This is a nonprofit, observational, prospective and retrospective,multicenter study in a population of young and adult patients ≥12 years with a diagnosis of a cardiac mass. The study will include both patients with masses of unknown pathological diagnosis and patients with a known histology of benign or malignant tumors. We predict a case-control allocation ratio of 1:1 between cardiac malignant tumors and benign lesions. Peripheral blood will be collected at participating centers during routine venipuncture,processed and then shipped for liquid biopsy ctDNA NGS analyses. If available, in malignant cases, matched tumor tissue samples collected as per clinical practice solid biopsies or surgery will be used for analyses. Longitudinal tracking through serial blood draws could be performed in selected cases of patients with cardiac malignancies who receive cancer treatment
- Condition
- Cardiac Masses
- Tested
- NGS-guided regimen: Regimen A
- Sponsor
- Niguarda Hospital
Who can join
- Age
- 12 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 4
- Minimum age: 12 years
- Study condition: Cardiac Masses
- Age ≥12 years old
- Suspected or confirmed diagnosis of a cardiac mass of any nature as assessed by standard clinical, radiological and/or pathological procedures.
Exclusion 1
- \. Inability of the pa ent to fully understand and sign the informed consent.
Where
1 site, 1 recruiting
Niguarda Hospital
Milan, Italia, Italy
Contact
-
Katia Bencardino, MD
+39026444 katia.bencardino@ospedaleniguarda.it
-
Giorgio Patelli, MD
+39026444 giorgio.patelli@ospedaleniguarda.it
Potential match only. Final eligibility is determined by the study team.