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Recruiting Phase 2

Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients

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About this study

The goal of this randomized, double-blind, placebo-controlled clinical trial is to determine whether dapagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, can help prevent anthracycline-induced cardiotoxicity caused by anthracycline chemotherapy in adult women with breast cancer receiving (neo)adjuvant treatment. The main questions the study aims to answer are: i) Does dapagliflozin reduce the decline in left ventricular function (measured by LVEF, GLS, and myocardial work) during and after anthracycline therapy? ii) Does dapagliflozin lessen the deteriorating effect of chemotherapy on endothelial function and arterial stiffness? iii) Does dapagliflozin effect levels of cardiac injury and inflammation biomarkers (e.g., hs-troponin T, NT-proBNP, ST-2, GDF-15, galectin-3, IL-6, MPO)? Researchers will compare dapagliflozin 10 mg daily with placebo to see whether those receiving dapagliflozin experience less heart and vascular impairment during treatment. Participants will: * Take either dapagliflozin or placebo once daily during anthracycline chemotherapy. * Undergo heart and vascular ultrasound, and a 6-minute walk test before chemotherapy and again at 24 and 52 weeks. * Provide blood samples before, during and after chemotherapy to measure cardiac biomarkers. * Complete multiple questionnaires on quality of life.

Condition
Heart Failure, Anthracycline-induced Cardiac Toxicity, Endothelial Function (FMD), Arterial Stiffness, Breast Cancer
Tested
Dapagliflozin 10 mg, Placebo
Sponsor
University Medical Centre Ljubljana

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 7

  • Minimum age: 18 years
  • Study condition: Heart Failure, Anthracycline-induced Cardiac Toxicity, Endothelial Function (FMD), Arterial Stiffness, Breast Cancer
  • Adults ≥18 years.
  • Histologically confirmed breast cancer with planned (neo)adjuvant anthracycline-based chemotherapy (4 cycles of epirubicin + cyclophosphamide or doxorubicin + cyclophosphamide).
  • Eligible to start dapagliflozin or placebo prior to or at initiation of chemotherapy.
  • Able to perform baseline echocardiography, vascular ultrasound (FMD and carotid stiffness), 6-minute walk test, and biomarker sampling.
  • Willing and able to provide written informed consent.

Exclusion 13

  • Known heart failure (any prior diagnosis of HF).
  • Clinically significant valvular heart disease.
  • Prior exposure to chemotherapy or radiotherapy to the left chest.
  • Type 1 diabetes mellitus.
  • Symptomatic hypotension.
  • History of recurrent urinary tract infections.
  • History of diabetic ketoacidosis or ketonemia.
  • Severe hepatic impairment (ALT, AST, ALP \>3× upper limit of normal).
  • Severe renal impairment (eGFR \<20 mL/min/1.73 m²).
  • Known allergy or intolerance to SGLT-2 inhibitors.
  • Any use of SGLT-2 inhibitor therapy within 3 months prior to enrollment.
  • Pregnancy or breastfeeding.
  • Any condition that, in the investigator's judgment, could interfere with study participation, safety, or completion.

Where

1 site, 1 recruiting

University Medical Centre Ljubljana

Ljubljana, Slovenia

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.