Multimodal Telerehabilitation in Patients Undergoing CAR-T Cell Immunotherapy
About this study
The proposed multimodal telerehabilitation model allows a rehabilitation therapy team to set up individualized rehabilitation plans using a web-based care management portal and monitor patient progress online. Patients at home follow a safe and effective personalized exercise and nutrition plan guided by interactive touch-screen technology combined with behavioral counseling, social support, and interactive education and empowerment. The design of the telerehabilitation system is based on the cloud-based Internet-of-Things architecture allowing real-time monitoring of cardiovascular parameters and exercise performance. The patient's level of exertion during exercise is automatically identified by a validated AI-driven algorithm supporting exercise safety and efficacy. The ultimate goal of this pilot feasibility project is to establish the extent of the impact of the proposed patient-centered cancer telerehabilitation model on disease-specific quality of life, and functional and symptom outcomes and to obtain sufficient evidence for a definitive randomized clinical trial evaluating this approach in a multi-center study.
- Condition
- Lymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity Syndrome
- Tested
- Home Automated Telemanagement (HAT) Patient Unit
- Sponsor
- University of Utah
Who can join
- Age
- 21 years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 7
- Minimum age: 21 years
- Study condition: Lymphoma, Myeloma, Cytokine Release Syndrome, Immune Effector Cell Associated Neurotoxicity Syndrome
- age \>21
- confirmed diagnosis of lymphoma or myeloma
- commercial FDA-approved CAR-T delivery planned for ≥4 weeks following enrollment
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Access to a working telephone line in their home or a cell phone.
Exclusion 4
- have unstable angina, uncontrolled hypertension, recent myocardial infarction, pacemakers, painful or unstable bony metastases, or recent skeletal fractures;
- are engaged in a regular exercise rehabilitation program;
- have relocation plans within next 6 months;
- participate in another clinical trial.
Where
1 site, 1 recruiting
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, United States
Contact
-
Aileen Gabriel
801-585-3229 aileen.gabriel@utah.edu
Potential match only. Final eligibility is determined by the study team.