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Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma

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About this study

This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.

Condition
Lepidic-Predominant Lung Adenocarcinoma, Lung Adenocarcinoma
Tested
Ketogenic diet, 2-[18F]FDG PET/CT
Sponsor
Fondazione del Piemonte per l'Oncologia

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 9

  • Minimum age: 18 years
  • Study condition: Lepidic-Predominant Lung Adenocarcinoma, Lung Adenocarcinoma
  • Written informed consent.
  • Age 18 years or older.
  • CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.
  • Target nodule diameter at least 10 mm.
  • ECOG performance status 0 to 2.
  • Willingness and ability to adhere to a controlled ketogenic diet for 7 days.
  • Ability to comply with study procedures and visit schedule.

Exclusion 9

  • Not suitable for prolonged imaging procedures.
  • Renal failure.
  • Type 1 diabetes mellitus.
  • Pancreatitis.
  • Severe dyslipidemia.
  • Other malignancies that are progressing or required active treatment within the previous 3 years.
  • Serious or unstable medical, psychiatric, or substance use disorders that could interfere with study participation.
  • Pregnancy or breastfeeding.
  • Refusal to participate

Where

1 site, 1 recruiting

Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060

Candiolo, Torino (TO), Italy

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.