Magnetic Resonance Imaging of the Lung: Oncological Applications
About this study
Lung neoplasms are characterized by a complex interaction between tumor cells and a variety of resident and infiltrating host elements, secreted factors, and extracellular matrix proteins, collectively referred to as the microenvironment. Nowadays, in the setting of lung cancer, and in particular non-small cell lung cancer (NSCLC), the evaluation of microenvironment characteristics can only be performed by a pathologist and only on histological material. By combining different MRI parameters, it may be possible to create a specific imaging "signature" for the three different immune phenotypes and thus be able to make a distinction based on MRI examination.
- Condition
- Lung Cancer (NSCLC)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Who can join
- Age
- 18 years and older
- Sex
- All sexes
- Healthy volunteers
- Not stated
Inclusion 5
- Minimum age: 18 years
- Study condition: Lung Cancer (NSCLC)
- Primary NSCLC of the lung (TNM 8th edition T parameter ≥T1c)
- Biopsy examination of the primary tumor adequate at least for PDL-1 quantification
- Staging CT scan with uncertain N parameter and definite M parameter.
Exclusion 1
- Absolute contraindications to magnetic resonance imaging or the administration of gadolinium-based contrast agents
Where
1 site, 1 recruiting
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Contact
-
Chandra Bortolotto
+390382503761 c.bortolotto@smatteo.pv.it
Potential match only. Final eligibility is determined by the study team.