Skip to content
TrialMatch
Sign up
Recruiting

Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS

Create a profile to match View the full record on ClinicalTrials.gov

About this study

To verify whether the transpulmonary pressure-guided mechanical ventilation strategy can reduce right ventricular involvement, especially the incidence of acute cor pulmonale (ACP), in patients with moderate to severe ARDS induced by pneumonia compared with the currently widely used right ventricular protective mechanical ventilation strategy.

Condition
ARDS (Moderate or Severe)
Tested
Transpulmonary pressure guided mechanical ventilation strategy
Sponsor
Beijing Chao Yang Hospital

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 7

  • Minimum age: 18 years
  • Study condition: ARDS (Moderate or Severe)
  • Age ≥ 18 years old
  • ARDS caused by pneumonia (New Global Definition of ARDS)
  • PaO2/FiO2≤200mmHg
  • Received invasive mechanical ventilation
  • Sign the informed consent form

Exclusion 13

  • Invasive mechanical ventilation duration \> 48 hours
  • History of pulmonary hypertension caused by various reasons
  • Severe arrhythmia
  • BMI\>30kg/m2
  • Contraindications to inserting an esophageal catheter (including recent esophageal injury or surgery, severe coagulopathy (platelets \< 5×10⁹/L or INR \> 4)
  • Pregnant and lactating women
  • Lung transplant recipient
  • High-risk factors for increased intracranial pressure (including intracranial hemorrhage, cerebral contusion, cerebral edema, intracranial space-occupying lesions, etc.)
  • Active air leakage in the lungs (pneumothorax, mediastinal emphysema, bronchopleural fistula, air leakage from closed thoracic drainage tubes, etc.)
  • Neuromuscular disease
  • Already received salvage measures (iNO, ECMO, prone position, high-frequency oscillatory ventilation)
  • Severe liver failure
  • Participated in other ARDS-related studies within 30 days

Where

1 site, 1 recruiting

Beijing Chao-Yang Hospital

Beijing, China

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.