Skip to content
TrialMatch
Sign up
Recruiting

MIMICC Study in Patients With Colorectal Cancer

Create a profile to match View the full record on ClinicalTrials.gov

About this study

This multicenter prospective interventional study will evaluate stool and saliva microRNA expression and microbiome composition in patients with histologically confirmed colon or rectal cancer during key phases of the diagnostic and therapeutic pathway. The study aims to confirm and refine molecular signatures associated with colorectal cancer, assess the diagnostic and prognostic potential of salivary biomarkers, and characterize dynamic molecular changes during treatment and follow-up

Condition
Colorectal Cancer, Colon Cancer, Rectal Cancers
Tested
Prospective Biological Sample Collection and Longitudinal Molecular Profiling, Diet and Lifestyle Assessment
Sponsor
Fondazione del Piemonte per l'Oncologia

Who can join

Age
18 to 75 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 9

  • Minimum age: 18 years
  • Maximum age: 75 years
  • Study condition: Colorectal Cancer, Colon Cancer, Rectal Cancers
  • Histologically confirmed colon or rectal cancer on endoscopic biopsy
  • Any T stage, any N stage, M0-M1, candidate for surgical intervention
  • Colon tumors with indication for surgical resection with curative intent, including right hemicolectomy, left hemicolectomy, transverse colon resection, colectomy, or total proctocolectomy
  • Rectal tumors with indication for upfront surgery or neoadjuvant chemoradiotherapy
  • Written informed consent signed before any study procedure
  • Age between 18 and 75 years

Exclusion 5

  • Tis/T1 lesions or lesions almost completely resected by endoscopic polypectomy/EMR/ESD
  • Use of immunosuppressive or immunomodulatory drugs within the previous 6 months
  • Current or previous diagnosis of other solid or hematologic malignancies
  • Inability or refusal to provide informed consent
  • Inability or refusal to be followed at the study institution/network

Where

1 site, 1 recruiting

Unit of Surgical Oncology - Fondazione del Piemonte per l'Oncologia- IRCCS Istituto di Candiolo, Candiolo, Turin 10060

Candiolo, Torino (TO), Italy

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.