Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
About this study
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD). The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance. Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
- Condition
- Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease
- Tested
- Computer-based facial expression recognition task, Computerized affective task, UCLA Structured Insight Interview, Barbe...
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Who can join
- Age
- 50 to 80 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 8
- Minimum age: 50 years
- Maximum age: 80 years
- Study condition: Frontotemporal Dementia, Behavioral Variant, Alzheimer Disease
- Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR
- Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group)
- Mini-Mental State Examination (MMSE) ≥ 20
- Age: 50-80 years
- Sufficient reading and writing proficiency in French to enable completion of the study procedures, in the investigator's opinion
Exclusion 5
- Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32
- Inability to perform computerized tasks according to the investigator's opinion
- Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia)
- Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode)
- Uncorrected visual impairment
Where
1 site, 1 recruiting
Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital Group, APHP
Paris, France
Contact
-
Emmanuel Cognat, MD PhD
+33 (0) 1 40 05 49 54 emmanuel.cognat@aphp.fr
Potential match only. Final eligibility is determined by the study team.