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A Smart Phone Application to Improve Adoption of the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) Guidelines

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About this study

The goal of this study is to establish whether use of a digital intervention can improve adherence and alignment with the Kidney Disease: Improving Global Outcomes (KDIGO) Chronic Kidney Disease (CKD) 2024 Guidelines. A subset of the study will focus on whether the intervention improves outcomes for young adults living with CKD, in the context of the imminent co-location of Children's Health Ireland on the St. James's Hospital campus. Young adults with CKD transitioning to adult services are recognised as a high-risk and vulnerable cohort, with many individuals unaware of increased cardiovascular risk and mortality¹². In response, and in the context of the co-location of Children's Health Ireland on the St. James's Hospital site, a young adult nephrology clinic has been established. The KDIGO CKD 2024 Guidelines identify transition as a period of increased risk and include recommendations regarding cardiovascular risk factor targets and the use of therapies known to delay CKD progression³. Electronic communication is a preferred method for accessing health information among many young adults⁴⁵ and aligns with Sláintecare digital health strategies⁶. A recently established, award-winning St. James's Hospital renal smartphone application is currently used by over 3,000 individuals living with CKD. The study aims to determine whether use of the application improves adherence to KDIGO guideline recommendations, with the objective of delaying CKD progression and associated complications. The application will support optimisation of care by signposting opportunities for evidence-based interventions (e.g., SGLT2 inhibitors, renin-angiotensin system inhibition) to healthcare providers. The application will also provide participants with tailored recommendations, reminders, educational materials, and collection of patient-reported outcome measures. Due to the diverse population and range of specialties at St. James's Hospital, the young adult clinic serves distinct subgroups, including individuals with sickle cell anaemia and survivors of cancer and haematological malignancies. These populations will be examined in the context of KDIGO guideline implementation, contributing to a limited international evidence base. This research evaluates an intervention designed to improve care for adults living with chronic kidney disease.

Condition
Chronic Kidney Disease, Proteinuria, Blood Pressure Control, Congenital Anomalies of the Kidneys and Urinary Tract, Nephrotic Syndrome, Sickle-Cell Nephropathy, Tuberous Sclerosis Complex, Cancer Survivors
Tested
Use of an electronic digital Application
Sponsor
St. James's Hospital, Ireland

Who can join

Age
16 to 30 years
Sex
All sexes
Healthy volunteers
Not accepted

Inclusion 7

  • Minimum age: 16 years
  • Maximum age: 30 years
  • Study condition: Chronic Kidney Disease, Proteinuria, Blood Pressure Control, Congenital Anomalies of the Kidneys and Urinary Tract, Nephrotic Syndrome, Sickle-Cell Nephropathy, Tuberous Sclerosis Complex, Cancer Survivors
  • Adults aged ≥16 years.
  • Diagnosed with CKD stages 1-5.
  • Owns a smartphone and is capable of using mobile applications.
  • Provides informed consent.

Exclusion 3

  • Inability to provide informed consent due to a neurocognitive impairment.
  • Age 30 years or older
  • The study will be conducted in the already established SJH Young Adult Clinic, with anticipated expansion coinciding with the co-location Children's Health Ireland (CHI) on site.

Where

2 sites, 2 recruiting

St. James's Hospital

Dublin, Ireland

Recruiting

Trinity College Dublin

Dublin, Ireland

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.