Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
About this study
The goal of this clinical trial is to evaluate whether a 4-week music therapy (MT) intervention can reduce chronic pain and improve psychosocial outcomes in youth with sickle cell disease (SCD). The main questions it aims to answer are: * Does MT reduce pain intensity, frequency of pain episodes, and improve health-related quality of life (HRQoL)? * Does MT alter immune cell composition and gene expression in inflammatory pathways, as measured by single-cell RNA sequencing (scRNA-seq)? Researchers will compare participants randomized to music therapy versus a control condition to see if MT produces superior improvements in pain and psychosocial outcomes, and distinct molecular changes.
- Condition
- Sickle Cell Disease
- Tested
- Music Therapy, Standard of Care
- Sponsor
- Emory University
Who can join
- Age
- 8 to 18 years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
Inclusion 9
- Minimum age: 8 years
- Maximum age: 18 years
- Study condition: Sickle Cell Disease
- Diagnosed with SCD
- English fluency (for survey completion)
- Have access to a personal electronic device (e.g., phone, tablet) with access to the internet
- Meet the criteria for chronic pain defined by the International Association for the Study of Pain (IASP). IASP defines chronic pain as pain that is both:
- Persistent or recurrent for ≥ 3 months
- is associated with significant emotional distress or functional disability.30
Exclusion 1
- Major hearing deficiency or medical condition in which listening to music may be contraindicated (e.g., reflex epilepsy).
Where
1 site, 1 recruiting
Children's Healthcare of Atlanta
Atlanta, Georgia, United States
Contact
-
Manoj Bhasin, PhD
404-712-9849 manoj.bhasin@emory.edu
Potential match only. Final eligibility is determined by the study team.