A Study of Lung Cancer Risk

Inclusion 16

• Minimum age: 40 years
• Maximum age: 74 years
• Study condition: Lung Cancer
• Criteria:
• Female at birth
• Age 40-74 years
• No smoking history
• Participants must be never-smokers, defined as having smoked \<100 cigarettes in their lifetime
• Documentation of disease - case patients
• o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
• Criteria for control participants
• Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules.
• Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively.
• Data regarding these participants will be reported in a sensitivity analysis.
• Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching.
• Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.