Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis
About this study
This observational cross-sectional study will evaluate salivary apelin, chemerin, ghrelin, and lipocalin-2 levels in individuals with different periodontal and systemic conditions. Participants will be divided into four groups according to periodontal status and the presence or absence of type 2 diabetes mellitus. Clinical periodontal measurements and unstimulated saliva samples will be obtained before periodontal treatment. Salivary biomarker levels will be measured using enzyme-linked immunosorbent assay kits. The study aims to determine whether salivary apelin, chemerin, ghrelin, and lipocalin-2 levels are associated with periodontitis, type 2 diabetes mellitus, and periodontal clinical parameters.
- Condition
- Periodontitis, Type 2 Diabetes Mellitus (T2DM)
- Tested
- Salivary Biomarker Analysis
- Sponsor
- Necmettin Erbakan University
Who can join
- Age
- 18 to 80 years
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 8
- Minimum age: 18 years
- Maximum age: 80 years
- Study condition: Periodontitis, Type 2 Diabetes Mellitus (T2DM)
- Individuals aged 18 to 80 years. Individuals who apply to the Department of Periodontology, Faculty of Dentistry, Necmettin Erbakan University.
- Individuals who agree to participate in the study and sign the informed consent form.
- Presence of at least 20 teeth. For the periodontally healthy groups: diagnosis of periodontal health based on routine clinical and radiographic examination.
- For the periodontitis groups: diagnosis of generalized Stage II or Stage III periodontitis based on routine clinical and radiographic examination according to the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.
- For the type 2 diabetes mellitus groups: diagnosis of type 2 diabetes mellitus. For the systemically healthy groups: absence of systemic diseases, including type 2 diabetes mellitus.
Exclusion 5
- Periodontal treatment, including scaling and root surface debridement, within the last 6 months.
- Antibiotic use within the last 6 months. Pregnancy or lactation. Presence of autoimmune diseases such as rheumatoid arthritis, familial Mediterranean fever, ankylosing spondylitis, Behçet disease, or psoriasis.
- Presence of systemic diseases other than type 2 diabetes mellitus in the diabetes groups.
- Presence of systemic diseases such as nephrotic syndrome, chronic renal disease, or cardiovascular disease.
- Smoking 10 or more cigarettes per day.
Where
1 site, 1 recruiting
Necmettin Erbakan University Faculty of Dentistry, Department of Periodontology
Konya, Konya, Turkey (Türkiye)
Contact
-
Osman Babayiğit
+90 506 320 84 74 obabayigit@erbakan.edu.tr
Potential match only. Final eligibility is determined by the study team.