More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
About this study
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.
- Condition
- Acute Lymphatic Leukemia, Lymphoma
- Tested
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement, Echocardioraphy, MRI, Clinical parameters, Blood sampl...
- Sponsor
- University of Erlangen-Nürnberg Medical School
Who can join
- Age
- 3 years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
Inclusion 11
- Minimum age: 3 years
- Study condition: Acute Lymphatic Leukemia, Lymphoma
- Control Group:
- no cancer diagnosis
- no lung diseases
- no vascular diseases
- No subjective reduction in physical performance
- age \>/= 18 years
- Completed therapy for ALL
- age \>/= 3 years
- Completed therapy for lymphoma
Exclusion 10
- Pregnancy, Lactation
- Known pleural or pericardial effusion
- Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
- Marked thoracic deformities/malformations
- Previous lung surgery
- Injuries that do not allow physical stress diagnostics
- Rejection of MRI imaging
- General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, copper IUD etc.)
- Survivors of ALL:
- Survivors of Lymphoma:
Where
1 site, 1 recruiting
Department of Pediatrics and Adolescent Medicine
Erlangen, Germany
Contact
-
Axel Karow, PD. Dr. med.
09131 8533118 axel.karow@uk-erlangen.de
-
Ferdinand Knieling, Prof. Dr. med.
09131 8533118 ferdinand.knieling@uk-erlangen.de
Potential match only. Final eligibility is determined by the study team.