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Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)

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About this study

OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological diseases. 840 patients with Central Nervous System neurological diseases (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease, migraine/headache) and 210 age-matched healthy controls will undergo OCT examination at baseline and at 6, 12, 18, and 24 months of follow-up at IRCCS San Raffaele Hospital, Milan, Italy. OCT is a non-invasive, rapid, and reproducible technique that automatically measures the thickness of individual retinal layers. Retinal layer thicknesses and their longitudinal changes will be correlated with established clinical scales, neuroimaging, and biological markers used in routine neurological practice.

Condition
Multiple Sclerosis, Alzheimer Disease, Parkinson Disease, Migraine, Headache Disorders
Tested
Optical Coherence Tomography (OCT) - Heidelberg SPECTRALIS HRA+OCT
Sponsor
IRCCS San Raffaele

Who can join

Age
18 years and older
Sex
All sexes
Healthy volunteers
Accepted

Inclusion 7

  • Minimum age: 18 years
  • Study condition: Multiple Sclerosis, Alzheimer Disease, Parkinson Disease, Migraine, Headache Disorders
  • Diagnosis of a Central Nervous System neurological disease (inflammatory diseases such as Multiple Sclerosis; neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease; migraine/headache) according to currently accepted diagnostic criteria for each condition.
  • Age greater than 18 years.
  • Signed informed consent to study participation.
  • Willingness and ability to undergo all study visits and procedures.
  • Absence of neurological disease.

Exclusion 6

  • Refusal to participate or withdrawal of informed consent.
  • Known or confirmed ocular pathology identified during examination (ophthalmological evaluation may be requested at the investigators' discretion).
  • Inability to understand instructions given by investigators.
  • Presence of any condition that, in the investigators' opinion, renders the subject unsuitable for the study.
  • For specific imaging modes using clearly visible light sources (MultiColor, FA, BAF): diagnosis of epilepsy or history of previous epileptic seizures.
  • Known or confirmed ocular pathology identified during examination.

Where

1 site, 1 recruiting

IRCCS Ospedale San Raffaele - Neurology and Neurophysiology Unit

Milan, Milano, Italy

Recruiting

Contact

Potential match only. Final eligibility is determined by the study team.